New findings about Alzheimer’s show where it starts

Scientists are taking a closer look at how Alzheimer's progresses. Credit: Metro file
Scientists are taking a closer look at how Alzheimer’s progresses.
Credit: Metro file

Researchers at Columbia University Medical Center have gained new insight into where Alzheimer’s disease starts and how it spreads throughout the brain, which could lead to earlier detection and thus more effective treatments.

The findings were presented in the journal Nature Neuroscience on Dec. 22.

Scientists have known that the degenerative disease starts in a part of the brain called the entorhinal cortex, says co-senior author Dr. Scott A. Small, director of the Alzheimer’s Disease Research Center. But he says his team’s study shows that it starts specifically in the lateral entorhinal cortex, which leads to the hippocampus (which we use for long-term memory). “If the LES is affected, other aspects of the hippocampus will also be affected,” he says.

The researchers also found that Alzheimer’s spreads out to other parts of the cerebral cortex, specifically the parietal cortex, which deals with spatial orientation and navigation. Alzheimer’s, they also learned, happens when changes to two particular proteins (tau and amyloid precursor protein) damage neurons in the LEC.

The study followed 96 people for an average of 3.5 years.


News
Entertainment
Sports
Lifestyle
Local

Video: Car crashes into Cambridge store, man arrested…

A Cambridge man was arrested on gun and drug charges after crashing his car into a Massachusetts Avenue storefront early Saturday morning.

Local

Body found believed to be missing Fitchburg boy…

The body of a child found off of a highway in Sterling last week is likely that of missing Fitchburg boy Jeremiah Oliver, authorities said.

Local

Memorial held for Sean Collier, MIT police officer…

More than 1,600 people gathered at MIT on Friday for a memorial service for Sean Collier, the police officer shot to death a year ago in the aftermath of the…

National

Florida man charged with murdering son to play…

A Florida man annoyed that his 16-month-old crying son was preventing him from playing video games suffocated the toddler, police said on Friday.

Television

'Orphan Black' recap: Episode 1, ‘Nature Under Constraint…

Welcome to your first Season 2 “Orphan Black” recap! Hopefully Tatiana Maslany can help Tatiana Maslany get through this, with the help of Tatiana Maslany,…

Entertainment

Whoopi Goldberg makes her debut as marijuana columnist

"It helps my head stop hurting, and with glaucoma your eyes ache, and she takes the ache out. It's wonderful," she said.

The Word

Kate Middleton made fun of Prince William's bald…

Kate Middleton and Prince William are in Sydney, Australia, right now, and it sounds like that brash Aussie sense of humor might be rubbing off.

The Word

Is Tom Cruise dating Laura Prepon?

"Mission: Impossible" star Cruise is said to be dating Laura Prepon, star of "Orange is the New Black."

MLB

MLB video highlights: Red Sox defeat Orioles, 4-2

Brock Holt the difference in the Red Sox' win

NHL

NHL video highlights & analysis: Red Wings dump…

NHL video highlights & analysis: Red Wings dump Bruins in Game 1

MLB

MLB video highlights: Orioles top Red Sox, 8-4…

John Lackey roughed up for second straight outing

MLB

MLB video highlights: Red Sox score two in…

Lester shines in Red Sox win over White Sox

Parenting

Is camp right for introverts?

We ask an expert for tips on sending your introverted child to camp

Parenting

How to parent without gender stereotypes in a…

Christia Spears Brown, Phd. author of "Parenting beyond Pink & Blue" gives advice on raising kids free of gender stereotypes.

Tech

VIDEO: 'Vein-scanning' may become the future of paying

Designed to make transactions quicker and easier, the technology works by scanning the unique vein patterns in each person's palm.

Tech

#FollowFriday: 10 of the smartest Twitter accounts

Spending lots of time on Twitter? You might as well learn something. Here are some of the smartest accounts to follow.