"Secretary Clinton is the most admired woman in the world," Simmons President Helen G. Drinan said in a statement announcing Clinton's appearance.
"She has dedicated her career to public service as an attorney, First Lady, Senator, and Secretary of State. As an advocate for women and girls, she has inspired millions of women to reach their full potential. Simmons is deeply honored to host such an exemplary role model."
The Simmons Leadership Conference is the longest-running women's leadership forum in the country, and annually attracts a global audience of more than 3,000 business and professional women.
This year's sold-out conference — "Jumping the Curve" — reflects the need to step away from the familiar and face the unknown in order to succeed, college officials said.
The conference can be followed live on Twitter @SimmonsLeads and #SLC14.