Victor Smith, 51, reportedly has not been seen since around 12:30 p.m. on Sunday, according to a witness who contacted police.
Smith reportedly suffers from schizophrenia and has not been taking his medication.
Smith's residence is near 32nd and York streets in Strawberry Mansion.
Smith is described as a 51-year-old black male, about 5'8" and weighing 150 pounds, with a dark complexion, brown eyes, and black curly hair. He was last seen wearing a blue T-shirt, a white jacket, black pants and black hat.
Anyone with information about Smith's whereabouts is being asked to call police.