A look at the best bets in the NFL for Week 10:

Arizona Cardinals at Seattle Seahawks (-3)

Both the Seahawks (4-4) and Cardinals (6-2) are fresh off their bye weeks for this important divisional showdown. Both teams have a strong defense, but Arizona has a tremendous advantage on offense, as it is ranked third in the league in YPG while Seattle is ranked just 19th.  The Seahawks have had trouble moving the chains this year partly because of their woeful offensive line, which has allowed Russell Wilson to be sacked 31 times, the worst mark in the league. The Cardinals don’t excel at generating pressure on the quarterback (tied for 27th in sacks) but they can induce mistakes, as they’ve forced a league-high 13 INTs on the year. Seattle will have a tough time alleviating the pressure on Wilson, as RB Marshawn Lynch will be forced to combat the NFL’s fourth-best run-stopping unit. Seattle is noted for having a strong home field advantage, but the Cardinals beat the Seahawks at CenturyLink Field in the December before Seattle won the Super Bowl, and Arizona is 5-1 ATS in their last six road contests. It should be a competitive game, but expect Carson Palmer and the Cardinals to escape with a narrow win. Grab the points just to be sure.

The pick: Cardinals +3


Miami Dolphins at Philadelphia Eagles (-6)

The Dan Campbell bandwagon has come to a screeching halt, as Miami has lost its last two games in blowout fashion under its newly-anointed head coach - who seemed to have righted the ship after two big wins against Tennessee and Houston. Expect the Dolphins’ slide to continue when they visit Philadelphia on Sunday. The Eagles have established a strong run game this season, averaging over 121 YPG on the ground, the 10th-best mark in the league. Their backfield trio of Ryan Mathews, DeMarco Murray and Darren Sproles should face little resistance from the Dolphins' 31st-ranked rushing defense, and they’ll control the time of possession. The Eagles “bend but don’t break” defense (ranked 13th in YPG allowed and 10th in PPG allowed) should be able to hold the line against a mediocre Dolphins attack (13th in YPG but 21st in PPG). Ryan Tannehill and Lamar Miller would have to have huge days through the air and on the ground in the limited time they’ll have the football to match the Eagles on the scoreboard. It’s worth noting Philadelphia is 7-3 ATS as home favorites in their last 10 games, so they take care of business in situations like this.

The pick: Eagles -6

RELATED: Hot Instagram pics of ESPN First Take host Molly Qerim


Carolina Panthers (-5) at Tennessee Titans

Any way you look at this matchup, the Panthers have a distinct advantage. Carolina is ranked 4th in PPG at 28.5, while Tennessee languishes in 27th at 19.9 PPG. The Panthers surrender only 20.6 PPG, while the Titans give up 23.4 PPG. Tennessee may have the third-best passing defense in football, but the Panthers like to run the ball. And they’ve done so successfully this year, ranking at the top of the league with over 140 YPG rushing, thanks mainly to Jonathan Stewart as well as QB Cam Newton, who can tuck-and-run with the best of them. The Titans have no answer for them. Titans QB Marcus Mariota will have nightmares about this game long after it’s over, as he’ll either be turning the ball over against the pick-happy Carolina defense (tops in the league at 13 INTs) or eating dirt all day long (the Panthers are ranked fourth in sacks with 25, while the Titans' O-line has allowed 28 sacks, fourth worst in the NFL). The venue will do little to help the Titans, as they are 3-7 ATS in their last 10 games at home, while the Panthers have covered in their last five road contests.

The pick: Panthers -5


Best of the rest (picks in bold)

Jacksonville Jaguars at Baltimore Ravens (-5.5)

New Orleans Saints (-1) at Washington Redskins

Chicago Bears at St. Louis Rams (-7)

Detroit Lions at Green Bay Packers (-11.5)

Cleveland Browns at Pittsburgh Steelers (-4.5)

Dallas Cowboys at Tampa Bay Buccaneers (-1)

Minnesota Vikings at Oakland Raiders (-3)

Kansas City Chiefs at Denver Broncos (-5.5)

New England Patriots (-7.5) at New York Giants



Houston Texans at Cincinnati Bengals (-10.5)