ImMucin: Potential cancer vaccine enters clinical trials

7af903ff7f80772debd8da0e5368a69f

In May, Vaxil BioTherapeutics Ltd., a private clinical stage biopharmaceutical company, announced that its researchers had published pre-clinical results from ImMucin, Vaxil’s lead therapeutic cancer vaccine, in the May edition of the scientific journal Vaccine.

The article entitled “ImMucin: a novel therapeutic vaccine with promiscuous MHC binding for the treatment of MUC1-expressing tumors”. Like a traditional vaccine, ImMucin helps the body’s immune system fight off bacteria or viruses — but unlike common vaccine, ImMucin is administered to people who are already sick.

ImMucin activates the immune system by
“training” T-cells which protect the body by
searching out and destroying cells that display a specific molecule called MUC1. MUC1 is generally found only on cancer cells and
not on healthy cells. The implications of this are that the T-cells won’t attack any cells that don’t contain MUC1, which means that the patient won’t experience the side effects which one experiences with traditional cancer treatments. With more than 90% of cancers having MUC1 on their cells, the implications could be groundbreaking.

In September, Vaxil also announced that it had
submitted a patent application to the United States Patent Office dealing with a novel use of signal peptides and naturally
generated auto-antibodies which would allow them to detect illnesses such as cancer earlier and provide a prognosis.

Dr. Lior Carmon, founder and CEO said in the press release in Nes-Ziona, “We have succeeded in identifying a
novel way to detect cancer onset and progression. This is an invaluable
tool which will significantly enhance our ability to provide effective
relief to these patients who are eligible to be treated with ImMucin and
is yet another validation of our VaxHit technology.”

ImMucin is
currently being evaluated in a Phase I/II clinical trial in Multiple
Myeloma patients at Hadassah Medical Center, Jerusalem. ImMucin is
potentially applicable to over 90% of all types of cancer, including
both solid and non-solid tumors. The vaccine aims to activate a compromised immune system and mobilize against the threat.


News
Entertainment
Sports
Lifestyle
Local

City Council budget asks for 1,000 additional NYPD…

Speaker Melissa Mark-Viverito unveiled the City Council's budget priorities on Wednesday, including the extra cops for the NYPD at a cost of $94.3 million.

Local

Behind the costumes at the Brooklyn Cosplay Fashion…

Echo Chronum, 17, is a quiet and reserved Brooklyn high school student who often buries herself in her homework. But there is another side to…

Local

Reddit helps man locate missing mother in New…

The Reddit community helped Josh Goldberg find his missing mother on Tuesday.

National

Hamas, Abbas's PLO announce reconciliation agreement

The Gaza-based Islamist group Hamas and President Mahmoud Abbas's Palestine Liberation Organization (PLO) agreed on Wednesday to a unity pact.

Television

TV watch list, Wednesday, April 23: 'Suburgatory,' 'Modern…

'Suburgatory' The men of "Suburgatory" go camping and Tessa mentors a social outcast in a Miss Chatswin contest, which brings her, once again, into conflict…

The Word

The best lines from Oprah's ex-stepmother's Daily Mail…

Oprah’s ex-stepmother, Barbara Winfrey, is out for revenge.

Books

A debut novel about fate, love and moving…

Pia Padukone talks about her debut novel, "Where Earth Meets Water."

Movies

Review: 'The Railway Man' is a literal-minded look…

In "The Railway Man," Colin Firth plays a WWII vet suffering from massive trauma acquired from his days as a beaten POW.

NBA

Phil Jackson talked to Steve Kerr, pushes for…

Knicks president Phil Jackson spoke to the media for the first time since firing head coach Mike Woodson on Monday.

MLB

Fantasy baseball: Searching for early season prospects

It’s relatively rare for a mediocre 30-year-old hitter to suddenly go nuts offensively for 162 games. That’s why minor league prospects are so exciting.

U.S. Soccer

NYCFC 'targeting' US international Mix Diskerud

Metro New York has learned Mix Diskerud has drawn “interest” from the expansion MLS side, NYCFC.

NFL

Jets announce they will return to Cortland for…

The tradition of holding camp in Cortland began in 2009 when Rex Ryan wanted to get his Jets away from the distractions of New York City.

Style

Pippa Middleton's Etsy pick: Golden Thread Jewelry

Get a look at the jewelry Pippa Middleton loves and find out how you can buy it too.

Parenting

What every parent needs to know to get…

Mom and author of "Small Talk," Tracey Blake, shares her five practical tips to help you develop your children's language skills.

Sex

Subway crush: Meet your soulmate on your commute

Read about a couple who has been 40 years after meeting on the train.

Tech

Happy birthday, Game Boy! The handheld console turns…

Nintendo's Game Boy turns 25 this week. To commemorate, we look at some of its better games, like "Tetris" and "The Legend of Zelda: Link’s Awakening."