Possible jet lag cure found in study of mice

(Credit: Getty Images)
Changing time zones can really take it out of you. Maybe not anymore. Credit: Getty Images

Scientists have found a genetic mechanism in mice that hampers their body clock’s ability to adjust to changes in patterns of light and dark, and say their results could someday lead to the development of drugs to combat jet lag.

Researchers from Britain’s Oxford University and the Swiss drug firm Roche used mice to analyze patterns of genes in an area of the brain called the suprachiasmatic nuclei, which regulate mammals’ biological rhythm.

They found that one molecule, called SIK1, is key to how the mice responded to changes in light cycles.

When the scientists blocked the activity of SIK1, the mice recovered faster from disturbances in their daily light and dark cycle that had been designed to induce a form of mouse jet lag.

If the corresponding mechanism can be found and similarly blocked in humans, jet lag may become a thing of the past, the researchers said in their study, published online in the journal Cell on Thursday.

“We’re still several years away from a cure for jet lag, but understanding the mechanisms that generate and regulate our circadian clock gives us targets to develop drugs to help bring our bodies in tune with the solar cycle,” said Russell Foster, director of Oxford’s sleep and circadian neuroscience institute.

He said such drugs could also have broader potential value, including for people with mental illnesses where sleep disturbances are common.



News
Entertainment
Sports
Lifestyle
National

Actor Tracy Morgan wasn't wearing seatbelt in June…

By Jonathan Stempel(Reuters) - Actor and comedian Tracy Morgan and others in his limousine were not wearing seat belts when their vehicle was struck by…

National

Connected cars: Is AT&T leaving Verizon in its…

By Marina Lopes and Bernie WoodallWASHINGTON/DETROIT (Reuters) - Verizon Communications, the No.1 U.S. wireless carrier known for its widespread coverage, is falling behind its biggest…

Local

Grand jury begins hearing evidence in Eric Garner…

A grand jury began hearing evidence Monday relating to the death of Eric Garner while in police custody in July. Garner, 43, of Staten Island,…

Local

Mayor announces plan for solar panels at city…

Mayor Bill de Blasio announced the planned installation of 24 new solar panels at city schools on Monday morning. The panels, a $28 million investment,…

Going Out

Taste what Lower Manhattan is cooking at today's…

The Lower Manhattan food scene has changed a lot in three years, which you can taste first hand when the neighborhood's food festival returns. On…

Television

Review: 'Selfie' tries to coast on the charm…

"Selfie" offers cute leads and some good jokes, but focuses too much on a vague distaste for social media.

Movies

Review: Jason Reitman's 'Men, Women & Children' is…

Jason Reitman's "Men, Women & Children" takes a hysterical and melodramatic look at disconnection in the digital age, turning strong actors into zombies.

Television

TV watch list, Monday, Sept. 29: 'Castle,' 'Mom'…

Tune in for the season premieres of "Castle," "Mom" and "NCIS: Los Angeles."

NFL

Ryan Quigley making a big impact for Jets…

Ryan Quigley, now in his second year as the Jets punter, had an exceptional afternoon with six punts for an average of 51.7 yards per punt.

NFL

3 positives to take from Jets loss to…

The Jets suffered another loss Sunday — 24-17 to the Lions — but the reason why it hurts so much for Jets fans is that…

MLB

Joe Girardi not confident David Robertson will return…

David Robertson was as seamless as anyone could be replacing Mariano Rivera as he converted 39 saves, with a 3.08 ERA and 96 strikeouts in 64 1/3 innings.

NBA

Carmelo Anthony preaches patience with new coach, offense

While star forward Carmelo Anthony said he’s “enthusiastic” and “optimistic” for the upcoming season, he still wants everyone — from within the locker room and…

Education

How to ace your private school interview

Getting ready for a private school interview can be daunting for many, most of whom might never have been in an interview situation before. We’ve…

Education

5 questions parents should ask while visiting private…

It can be hard to know what to look for when searching for a new school for your child. Parents considering several different schools can…

Education

3 ways to save money on college application…

With the average high school student applying to 5 or 6 schools, hefty application and test score fees can add up quickly. We’ve compiled some…

Education

Nap rooms: The latest college campus trend

College is a time filled with new experiences (and lots of schoolwork), leaving little time for students to get a good night’s rest. University of…