Possible jet lag cure found in study of mice

(Credit: Getty Images)
Changing time zones can really take it out of you. Maybe not anymore. Credit: Getty Images

Scientists have found a genetic mechanism in mice that hampers their body clock’s ability to adjust to changes in patterns of light and dark, and say their results could someday lead to the development of drugs to combat jet lag.

Researchers from Britain’s Oxford University and the Swiss drug firm Roche used mice to analyze patterns of genes in an area of the brain called the suprachiasmatic nuclei, which regulate mammals’ biological rhythm.

They found that one molecule, called SIK1, is key to how the mice responded to changes in light cycles.

When the scientists blocked the activity of SIK1, the mice recovered faster from disturbances in their daily light and dark cycle that had been designed to induce a form of mouse jet lag.

If the corresponding mechanism can be found and similarly blocked in humans, jet lag may become a thing of the past, the researchers said in their study, published online in the journal Cell on Thursday.

“We’re still several years away from a cure for jet lag, but understanding the mechanisms that generate and regulate our circadian clock gives us targets to develop drugs to help bring our bodies in tune with the solar cycle,” said Russell Foster, director of Oxford’s sleep and circadian neuroscience institute.

He said such drugs could also have broader potential value, including for people with mental illnesses where sleep disturbances are common.



News
Entertainment
Sports
Lifestyle
Local

MTA announces service changes for Sunday

The MTA has announced service changes ahead of Sunday's People's Climate March, which will be held from 11:30 a.m. to 4:30 p.m. Sunday. Riders using…

Local

NYPD launches Twitter account for L train

The NYPD recently launched a Twitter handle dedicated to the L train and its riders. According to @NYPDLtrain, officers went underground Thursday morning to hand…

Local

Bushwick community space offers activists a place to…

A new Bushwick community space offers community activists to meet, create, learn and throw back a few cold ones. MayDay, located 214 Starr Street in Bushwick,…

Local

Activists gearing up for Sunday's "historic" People's Climate…

If all goes according to plan, more than 100,000 people will gather near Central Park West on Sunday morning and march through midtown to raise…

Movies

Kevin Smith makes peace with the Internet

I was thinking about Ain't It Cool News and Harry Knowles last night, wondering if anyone from Ain't It Cool had reviewed my new movie…

Movies

Art imitates life in 'Swim Little Fish Swim'

There's a certain comfort to be taken in finding that young artists are still moving to New York and trying to make it — and…

Movies

Review: Terry Gilliam's 'The Zero Theorem' is better…

Terry Gilliam's latest, "The Zero Theorem," concerns a reclusive malcontent (Christoph Waltz) struggling with the search for the meaning of life.

Music

Esperanza Spalding and a being called Emily get…

Esperanza Spalding is about to spiral off in a brand new direction that may or may include an alter ego named Emily.

NFL

Oday Aboushi ready for increased role, and to…

Oday Aboushi might feel comfortable enough to engage in some trash talk the next time he is on the field.

NFL

Giants vs. Texans: 3 things to watch

The Giants host the surprising Texans (2-0) in what may already be a must-win game for Big Blue.

NFL

Eric Decker misses practice again, could miss Monday

Jets wide receiver Eric Decker missed practice Thursday as he continues to rehab a hamstring injury suffered last Sunday.

MLB

Derek Jeter still focused on baseball as final…

Derek Jeter has effectively hid his emotions for 20 years in the Bronx.

Parenting

A sneaky way to serve kids fruits and…

"My First Juices and Smoothies" gives smoothie recipes for kids.

Style

3 things we love from Day 1 of…

The highlights from Day 1 of Milan Fashion Week.

Sex

Why don't more couples use condoms?

  Call it the “condom moment.” That’s the name the authors of a new study have given to the pivotal conversation every couple should be…

Sex

Need an idea for a first date? Here's…

Picture your idea of a nice first date. Is it dinner and a movie? A visit to an interesting museum exhibit? Instead, an expert on…