Mass. doctor helped treat girl ‘cured’ of HIV

Doctors say an HIV-positive baby who received immediate, aggressive treatment now shows no signs of the virus. (Getty Images)
Doctors say an HIV-positive baby who received immediate, aggressive treatment now shows no signs of the virus. (Getty Images)

In what’s being called a “functional cure,” doctors say a Mississippi girl born with HIV who received aggressive, early treatment now shows no signs of the virus that causes AIDS.

Dr. Katherine Luzuriaga, an immunologist at the University of Massachusetts Medical School, worked with researchers at Johns Hopkins in Baltimore and doctors at the University of Mississippi Medical Center on girl’s treatment.

“This is the very first case in which we’ve conclusively been able to document that the baby was infected and then after a period of treatment has been able to go off treatment without viral rebound,” Luzuriaga told CNN.


When the baby girl was born in a rural hospital in July 2010, her mother had just tested positive for HIV infection. Because her mother had not received any prenatal HIV treatment, doctors knew the child was at high risk of infection. They transferred her to the University of Mississippi Medical Center in Jackson, where she came under the care of Dr. Hannah Gay, a pediatric HIV specialist.

Because of her risk, Dr. Gay put the infant on a cocktail of three HIV-fighting drugs when she was just 30 hours old. Two blood tests done within the first 48 hours of the child’s life confirmed her infection and she was kept on the full treatment regimen, according to Dr. Deborah Persaud, a virologist with Johns Hopkins Children’s Center.

“This is a proof of concept that HIV can be potentially curable in infants,” Persaud said. She is lead author of a report presented at the Conference on Retroviruses and Opportunistic Infections in Atlanta.

More testing needs to be done to see if the treatment would have the same effect on other children, but the results could change the way high-risk babies are treated and possibly lead to a cure for children with HIV, the virus that causes AIDS.

“On the ultra-sensitive testing, we are occasionally getting signals so we cannot say with certainty that this child is absolutely clear of HIV, but we will continue to follow up with the baby,” Luzuriaga told CNN. “We have formed a hypothesis and that is already driving the design of new studies and clinical trials that will help us to answer the question of whether by coming in very early we will be able to treat children for a while and then remove them from therapy.”

The child’s story is different from the now famous case of Timothy Ray Brown, the so-called “Berlin patient,” whose HIV infection was completely eradicated through an elaborate treatment for leukemia in 2007 that involved the destruction of his immune system and a stem cell transplant from a donor with a rare genetic mutation that resists HIV infection.

“We believe this is our Timothy Brown case to spur research interest toward a cure for HIV infection in children,” Persaud said at a news conference.

With additional reporting by Reuters.

Follow Metro Boston on Twitter: @MetroBos



News
Entertainment
Sports
Lifestyle
Local

Mayor announces public housing improvements

Mayor Bill de Blasio spoke at the Lincoln Houses in East Harlem on Wednesday, calling for the scaffolding to come down at NYCHA complexes across…

National

Peter Theo Curtis: American released by Syrian militants…

An American writer freed this week from two years in the captivity of insurgents in Syria spoke briefly outside his family's Cambridge home Wednesday of…

Local

Bratton defends 'broken windows' work as NYPD support…

Sixty percent of those polled said they support the "broken windows" theory approach popularized by Commissioner Bratton since his first term in the 1990s.

Local

Transit changes for Labor Day weekend

The MTA is adding additional service Friday for New Yorkers getting out of the city for the long weekend. On Friday, Aug. 29, 27 additional…

Television

'So You Think You Can Dance' recap: Season…

Season 11’s top four dancers gave their final performances before America’s Favorite Dancers are announced next week.

Going Out

Things to do this week in NYC, Aug.…

MUSIC The Electric Zoo Festival Aug. 29-31, 1 p.m. Randall’s Island Park $99-$369, www.electriczoofestival.com The electronic music celebration returns for a fifth year, with 150,000 attendees…

Going Out

5 things to do this weekend in NYC

The Electric Zoo Festival Aug. 29-31, 1 p.m. Randall’s Island Park $99-$369, www.electriczoofestival.com The electronic music celebration returns for a fifth year, with 150,000 attendees expected. David Guetta,…

Television

'Full House' might be relaunched with some of…

A new "Full House" might be in the works.

NFL

Mario Manningham on the bubble as Giants play…

Former Super Bowl hero Mario Manningham hopes his second go-around with Big Blue doesn’t end with Saturday’s final cut day.

NFL

Source: Stephen Hill 'faces a battle' to make…

A team source says Stephen Hill, who has battled injuries and poor performances during his first two years, is no lock to make the Jets’ final roster.

Sports

Serena Williams leaving legacy of talented American women…

It seems only a matter of when, not if, Serena Williams will win her 18th career grand slam championship.

College

When are 2014 college football playoffs? (Schedule, date,…

When and where are 2014 college football playoffs? A look at the schedule, date, TV, time for the semi-finals at championship game.

Food

Recipe: Samuel Adams beer-marinated grilled shrimp

Summer calls for two things: a cold beer and light food. Sam Adams' Latitude 48 IPA fairly bursts with citrus notes, making it an ideal marinade…

Wellbeing

Heart trumps brain when it comes to movies…

When you need a good cry, do you reach for the movie that’s “based on a true story”? Science says you’re giving your brain far…

Sex

The 10 types of people you meet online

Does it ever seem like online dating profiles tend to get a little repetitive? It turns out you are not the only one to have…

Home

Labor Day essentials

Whether you’re soaking up the sun on the beach or barbecuing in the park here are some must-haves for your end-of-summer bash.