The Phillies mustered just three hits off five Cleveland pitchers Wednesday night in losing to the Indians, 6-0.
The Indians (12-13) got all the offense they would need in the second inning on Mike Aviles' sacrifice fly off Cliff Lee to score Carlos Santana.
Lee gave up five runs (four earned) on nine hits over six innings. Now 2-2 on the season, the lefty struck out four and walked two.
It was Lee's first start in Cleveland since the Indians traded him to Philadelphia in 2009.
Ryan Raburn, who hit two home runs to help Cleveland win Tuesday night, was 4 for 5 with two RBI for Cleveland.
Cleveland starter Trevor Bauer overcame control issues to pick up the win. He walked six in five innings, but only surrendered one hit in keeping the Phillies off the scoreboard.
The Phillies (12-16) return home to face the Miami Marlins over the weekend following a 3-2 road swing that included a sweep of the New York Mets.