The Chicago Cubs beat the Phillies on the rookie's home run in the ninth inning Wednesday night.
Murphy's three-run blast off relief pitcher Justin De Fratus sealed the deal for the Cubs, who took the game by a score of 5-2.
It was Murphy's third home run in two games against the Phillies this week. The infielder, who played third base Wednesday night, made his big league debut for the Cubs (50-63) on Sunday.
Murphy also hit a home run in the third inning off starting pitcher Cole Hamels. He was 3-for-3 on the night with 4 RBIs.
Domonic Brown, who returned from the DL Tuesday night, hit his 25th home run of the season for the Phillies last night. It was a solo home run.
The Phillies scored their other run on a RBI single by Chase Utley in the seventh inning. Utley reportedly signed a two-year contact extension worth $27 million before Wednesday's game.
The Phillies (51-62) could not muster any offense in the ninth off Cubs closer Kevin Gregg, who picked up his 23rd save of the season, after Murphy stroked the game-winning shot into the left field seats at Citizens Bank Park.