MADRID (Reuters) - Real Madrid midfielder Casemiro has suffered a fracture in his left leg, the La Liga club said on Thursday.

The Brazil international was substituted in Real's 2-0 win over Espanyol on Sunday and played no part in Wednesday's 1-1 draw with Villarreal.

"Following tests carried out today on Casemiro at the Sanitas La Moraleja University Hospital, he has been diagnosed with a fracture to the central third of his left fibula. His recovery will continue to be assessed," the club said in statement.

The 24-year-old, who has made five appearances in all competitions for Madrid this season, is likely to miss Brazil's World Cup qualifiers against Bolivia and Venezuela next month.

(Reporting by Toby Davis, editing by Pritha Sarkar)