Two drivers are on the run and one is facing a manslaughter charge after a deadly weekend that claimed the lives of two bicyclists and one pedestrian.

The first incident occurred on Saturday at about 12:40 a.m. when police discovered 26-year-old Giovanni A. Nin lying on the road with severe trauma on his body near East Tremont and Mayflower avenues in the Bronx, according to authorities.

Upon further investigation, police determined that Nin had been riding his bicycle along East Tremont Avenue when he tried to cross, mid-block, and was struck by a silver BMW X5, cops said. The driver drove off and emergency personnel later pronounced Nin dead the scene.

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The NYPD has released video of the vehicle involved in this incident and say it suffered damage to its front right bumper, hood and windshield.

Later that night another vehicle struck a bicyclist, this time in Manhattan near Chambers and West streets.

According to police, at around 7:52 p.m. cops found that a 2011 Ford truck — driven by Samuel Silva, 26, from New Jersey — was making a right turn to westbound Chambers Street when it struck a woman riding her bicycle southbound on West Street.

The victim was taken to Bellevue Hospital where she was later pronounced dead from sustaining trauma to her head and body.

Silva drove away from the scene but was later detained near Warren Street and North End Avenue, police said. He has since been charged with manslaughter, leaving the scene of an accident, failure to yield to a pedestrian, and driving while ability impaired.

Just hours later at 1:19 a.m. on Sundayin the Bronx aSUV struck 62-year-old Sharon Smith as she was attempting to cross East Gun Hill Road, police said.

Smith was found lying on the road near East Gun Hill Road and White Plains Road with severe trauma to her body, according to cops. She was taken to Montefiore Hospital where she was later pronounced dead.

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According to police, Smith was struck by a dark colored SUV traveling eastbound on East Gun Hill Road and which later drove away from the scene.

The NYPD has also released video of the vehicle involved in this incident.

Anyone with information in regards to these incidents is asked to call the NYPD's Crime Stoppers Hotline at 1-800-577-TIPS (8477) or for Spanish, 1-888-57-PISTA (74782).

The public can also submit their tips by logging onto the Crime Stoppers website or by texting their tips to 274637 (CRIMES) then enter TIP577.