Pittsburgh ranked 29th on the Economist Intelligence Unit's list of most liveable cities, the highest rated American city on the list.
Vancouver topped the list of the world's most liveable cities for the fifth straight year, while Melbourne claimed second place from Vienna and Australian and Canadian cities dominated the list's top 10 spots.
In the annual survey by the Economist Intelligence Unit, as reported by Reuters, the Canadian west coast city and 2010 Winter Olympics host scored 98 percent on a combination of stability, health care, culture and environment, education, and infrastructure — a score unchanged from last year.
It has topped the list from 2007.
Although Melbourne nipped the Austrian capital for silver medal, there was no other major change near the top of the list of 140 cities worldwide. Auckland, New Zealand, came in 10th.
"Mid-sized cities in developed countries with relatively low population densities tend to score well by having all the cultural and infrastructural benefits on offer with fewer problems related to crime or congestion," said Jon Copestake, editor of the report, in a statement.
Pittsburgh was the top U.S. city with 29th place -- just ahead of Honolulu -- while Los Angeles moved up three places to 44th and New York held onto the 56th spot.
London moved up one place to 53rd while Paris came in at number 16.
The top Asian city was Osaka at number 12, tying Geneva, Switzerland and beating out the Japanese capital of Tokyo, which came in at 18.
Hong Kong came in at 31 but Beijing, capital of the world's most populous nation and No. 2 economy, straggled in at 72.
There was also little change at the bottom, with Harare, the capital of Zimbabwe, once again claiming the worst position with a rating of 37.5 percent, narrowing beating out the Bangladesh capital of Dhaka.
The Economist Intelligence Unit survey ranks cities based on 30 factors such as healthcare, culture and environment, and education and personal safety.