An unmanned Antares rocket exploded seconds after lift off from a commercial launch pad in Virginia on Tuesday, a NASA TV broadcast showed.
The 14-story rocket, built and launched by Orbital Sciences Corp, bolted off its seaside launch pad at the Wallops Flight Facility at 6:22 p.m. EDT carrying a Cygnus cargo ship for the International Space Station. It exploded seconds later.
The cause of the accident was not immediately known, said NASA mission commentator Dan Huot.
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NASA said there were no injuries.
"This has been a lot of hard work to get to this point," Orbital Sciences Executive Vice President Frank Culbertson told the launch team just before liftoff.
Launch had been delayed one day after a boat sailed into a restricted safety zone beneath the rocket's intended flight path.
Virginia-based Orbital Sciences is one of two companies hired by NASA to fly cargo to the station after the space shuttles were retired. Tuesday's planned flight was to be the third of eight under the company's $1.9 billion contract with NASA.
The second U.S. supply line to the station is run by privately owned Space Exploration Technologies, or SpaceX, which is preparing for its fourth flight under a separate, $1.6 billion NASA contract.
Outfitted with a new, more powerful upper-stage engine, the Antares rocket launched on Tuesday carried a Cygnus spacecraft packed with 5,055 pounds (2,293 kg) of supplies, science experiments and equipment, a 15 percent increase over previous missions.
Cygnus was to loiter in orbit until Nov. 2, then fly itself to the station so astronauts can use a robotic crane to snare the capsule and attach it to a berthing port. The station, a $100 billion research laboratory owned and operated by 15 nations, flies about 260 miles (418 km) above Earth.
In addition to food, supplies and equipment, the Cygnus spacecraft was loaded with more than 1,600 pounds (725 kg) of science experiments, including an investigation to chemically analyze meteors as they burn up in Earth’s atmosphere.
The Cygnus also carried a prototype satellite owned by Redmond, Washington-based startup Planetary Resources Inc., which is developing technology to mine asteroids. The satellite, designated A3, was to be released into space by a commercially owned small spacecraft launcher aboard the station.