At least one student was shot on the campus of South Carolina State University, the school said on its Twitter account on Friday.
The university locked down its campus as police searched for a suspect, the school said.
"Police have not yet apprehended a suspect but they are currently in pursuit of the person they believe to be the perpetrator," it said.
The university did not say whether the shot student had been wounded or killed.
South Carolina State University is a historically black college in Orangeburg, about 75 miles northwest of Charleston.
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The university has an enrollment of some 3,200 students