The animated heroes of “Toy Story 3” crushed new releases from Adam Sandler and Tom Cruise to lead the North American box office for a second weekend, according to studio estimates issued yesterday.


“Toy Story 3,” from Walt Disney Company’s Pixar Animation unit, sold about $59 million worth of tickets across the United States and Canada during the three days beginning on Friday.


Its 10-day haul rose to $226.6 million, quickly making it the fourth-biggest movie of the year behind “Alice in Wonderland,” “Iron Man 2” and “Shrek Forever After.”


The Sandler-led ensemble comedy “Grown Ups” followed with $41 million — the fourth-best of his consistently strong career. The critically maligned picture, which co-stars Kevin James, Chris Rock, David Spade and Rob Schneider, was released by Columbia Pictures.


“Knight and Day” opened at a distant No. 3 with $20.5 million, far short of the tallies of Cruise’s last big movies (“Mission Impossible IV” and “War of the Worlds”).