49ers 23, Colts 26 (OT)
Two touchdowns in the game's final eight minutes from the 49ers forced things into overtime. The second coming with just 24 seconds. But the Colts would come out victorious after Adam Vinatieri's game-winning 51-yard field goal with 3:39 remaining in the extra frame.
Jets 17, Browns 14
The Jets have a winning record, a shocking fact considering this team wasn't supposed to win more than one or two games entering the season. Josh McCown passed for two touchdowns while Browns rookie DeShone Kizer was benched at halftime.
Jaguars 30, Steelers 9
In one of the most surprising results of the week, Ben Roethlisberger threw five interceptions against a solid Jaguars secondary with two of them being returned for touchdowns. Rookie running Leonard Fournette rushed for 181 yards on the day, including a 90-yard touchdown in the fourth quarter.
Chargers 27, Giants 22
Eli Manning's fumble with less than five minutes remaining set up Los Angeles' game-winning touchdown, a 10-yard connection from Philip Rivers to Melvin Gordon. The Giants are 0-5 for the second time since the 2013 season.
Bills 16, Bengals 20
Cincinnati is now winners of two straight after slowing down the Bills, who entered Week 5 in first place in the AFC East. An A.J. Green 77-yard touchdown reception highlighted the Bengals' big day as they held Buffalo to just 221 total yards.
Panthers 27, Lions 24
The Panthers had to stave off a late comeback attempt from the Lions, who scored 14 fourth-quarter points to almost overturn a 27-10 deficit. After drawing within three with three minutes left, the Panthers were able to run the clock out after a big 17-yard completion from Cam Newton to Kelvin Benjamin on a 3rd-and-9 with 2:30 left.
Titans 10, Dolphins 16
Jay Cutler hit Jarvis Landry for a six-yard touchdown pass with 4:56 left in the fourth quarter to break 10-10 tie and lift the Dolphins to their second win of the season. Cutler threw for just 92 yards on the afternoon.
Cardinals 7, Eagles 34
Carson Wentz spun together a gem of a day, completing 21-of-30 passes for 304 yards and four touchdowns. Three of them came in the first quarter as the Eagles put this game away early. The defense was just as solid, conceding just a second-quarter touchdown.