The Red Sox (27-25) took Game 1 of their three-game set with the Blue Jays at The Rogers Centre Friday night, 7-2.
Clay Buchholz earned his fifth win of the season for Boston, pitching 8 innings, allowing two earned runs on six hits.
David Ortiz and Adrian Gonzalez provided the early damage for the Red Sox with a home run and RBI single, respectively.
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Boston had a big seventh inning to separate themselves from Toronto, scoring four runs courtesy of big hits by Daniel Nava, Ortiz and Gonazalez.