Jarrod Saltalamacchia's two-run homer in the bottom of the ninth sent the Fenway faithful into a frenzy Tuesday night as Boston tied the game 6-6 and headed to extra innings.
Baltimore, however, had enough of the excitement as Ronny Paulino and Endy Chavez drove in runs in the 10th inning and Baltimore escaped with an 8-6 victory.
Alfredo Aceves took the loss for Boston.
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Tuesday's starter, Jon Lester, allowed two earned runs on eight hits in six innings.
Mike Aviles had three hits for Boston in the loss.