The Revs are a win or tie away from their fourth MLS Eastern Conference finals berth in five years.
After beating the Chicago Fire 2-1 at Gillette Stadium on Saturday, New England is on the verge of another deep playoff run despite suffering through an injury-plagued campaign.
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Shalrie Joseph, who was sidelined with a sprained knee earlier this year, scored the decisive goal to position New England to advance through the two-game, aggregate series.
If the Fire tie the Revs on aggregate goals with a one-score win on Saturday, the two teams will play two 15-minute overtime periods before proceeding to penalty kicks if still deadlocked.
The big upset from the first weekend of action was at Rio Tinto Stadium in Utah, where Real Salt Lake, the lowest seed in the Cup, beat the Columbus Crew, which had the most points in MLS, 1-0.