The Bruins struggled with lowly Tampa Bay Tuesday night as they fell, 5-3, on the road.
The Lightning ended a seven-game losing streak with the victory.
Daniel Paille knotted the game at three in the third period while Dominic Moore gave the Lightning the lead with 3:45 left and Steven Stamkos would score as time expired.
Nathan Horton had two goals for the Bruins. Tim Thomas took the loss in goal.
Boston plays in New Jersey against the Devils Thursday night.
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