DRAMA. Eric McCormack plays a genius neuroscience professor who, despite his schizophrenia and inability to distinguish real people from hallucinations, teams up with the FBI (Rachael Leigh Cook, playing his former student-turned-agent) to help solve crimes.

Series premiere, 10 p.m., TNT


"The Closer"

DRAMA. Woah, there, Brenda. You may think you’ve finally nailed your nemesis, Philip Stroh (guest star Billy Burke), but you’ve still got one season left to fill before you actually convict him.

Season premiere, 9 p.m., TNT


"Bizarre Foods America"

REALITY. For his 100th episode, host Andrew Zimmern heads to Las Vegas, where he finds $750 cupcakes, $1,000 sundaes and a hamburger priced at $5,000. Bizarre, indeed.

Season premiere, 9 p.m., Travel Channel


"Opening Act"

REALITY. YouTube talent gets the opportunity to open for arena-worthy acts like Rod Stewart and LMFAO.

Series premiere, 10 p.m., E!