Actress Drea De Matteo lost her home of 22 years in Thursday's East Village explosion. 

The "Sopranos" actress tweeted, "NYC's finest trying to put out the flames to mine n many others apartments. Speechless..." and posted a photo of FDNY firefighters hosing down the fire.

The explosion occurred on Second Avenue between East 7th and 8th Streets and led to the collapse of two buildings.

Four buildings caught fire, including De Matteo's, and 12 people were treated for their injuries, including three who were in critical condition. One man is still missing

De Matteo posted a shocking photo of her apartment building, pulverized into a pile of debris. She wrote, "A hole where my NYC home of the last 22 years once stood ...  RIP 123 2nd Avenue" on Instagram.

De Matteo also wrote to pray for those that are hurt.