Sam Simon, co-creator of "The Simpsons," died on Monday after a battle with colon cancer. Simon, 59, was diagnosed with terminal cancer in 2013.

The Sam Simon Foundation announced on Facebook, "It is with much sadness that we must let you know that Sam Simon has passed over. We all miss him, and in his honor, we will continue bringing his vision to light through our work at The Sam Simon Foundation. We take comfort in knowing how many greetings he is receiving across that Rainbow Bridge. We love you Sam!"

Simon's most successful endeavor was co-creating "The Simpsons" with Matt Groening and James L. Brooks. The three showrunners worked together on "The Tracey Ullman Show" and created shorts featuring the Simpsons family that aired on "The Tracey Ullman Show." "The Simpsons" debuted as a primetime TV show in 1989. 

Simon left the show in 1993 but left with a deal to receive royalties and credits after the show; he retired in his mid-30s, reports the Hollywood Reporter

Simon was a known animal lover, and the Sam Simon Foundation was dedicated to rescuing stray dogs. He has given millions to various animal welfare charities.