The injury bug is sending fantasy football team owners to the waiver wires a few extra times this week, with a few mid-week developments with big implications coming down the pipeline.
Here are few players who made headlines for the wrong reasons:
Eddie Lacy, Packers
The Packers' big downhill runner was ruled out for Thursday Night Football on Wednesday, not surprisingly, and is expected to miss a few weeks due to an ankle injury. The team traded a conditional draft pick to the Chiefs for Knile Davis earlier in the week and he and James Starks will get the lion's share of the carries in Week 7.
Doug Martin, Buccaneers
A small setback was reported in the recovery of Martin from a hamstring injury and the back is expected to miss several more weeks. With Charles Sims also sidelined, Jaquizz Rodgers will once again start at running back for Tampa Bay.
LeSean McCoy, Bills
After turning in one of his best career performances against the Niners on Sunday, McCoy was unable to complete Wednesdays practice due to a tight hamstring.
"We'll see how it goes," Buffalo coach Rex Ryan said.
McCoy's status is up in the air, but if the NFL's second-leading rusher is unable to play in Week 7, Mike Gillislee will get the start.
Ben Roethlisberger, Steelers
Big Ben had surgery for his knee earlier this week and the news isn't good. He will likely miss extended time — with Landry Jones working under center in his absense.
"I think that two to three is what you can characterize as best-case, but that's what we're hoping for," Steelers president and co-owner Art Rooney said. "Two to six is probably a fair range that somebody can put on it."
Geno Smith, Jets
The Jets are 1-5 and in desperation territory, so the coaching staff decided to mix things up. After Smith took the field in relief of Ryan Fitzpatrick in Monday night's loss, many thought it was just that, a mop-up appearance. But Wednesday, Todd Bowles made it official, Smith is back on top of the depth chart.
"Geno's our starter. Ryan's the No. 2," Bowles said. "I felt like it was time for a change. This was strictly my call."