Running backs took the brunt of the injury bug in Week 2, with seven top-tier rushers leaving their respective games with leg injuries.
A few wide receivers, tight ends and quarterbacks also had big setbacks Sunday. Here's a look at the latest on a few key fantasy football players:
The Jets' wide receiver will be helped by the long week, after sustaining an MCL injury in Thursday's win against the Bills, Marshall's status for Week 3 is unknown — though Pro Football Talk says he is not a lock to play. The team affirms that they are optimistic.
If Marshall sits, the already surging Eric Decker will be a huge contributor against the Chiefs. It's also a good idea to monitor or pick up Quincy Enunwa.
The Patriots are in no hurry to rush Gronkowski back, as the team will likely be content to have him return alongside Tom Brady in a few weeks. He remains a gametime decision and is practicing lightly. His backup Martellus Bennett has been performaning very well in his stead, and should be a fantasy staple regardless of Gronk's status.
The Colts wideout took a big hit Sunday and exited the game immediately after. A Monday MRI will determine if he can go in Week 3.
If he doesn't play, locate Phillip Dorsett on the waiver wire.
The Seahawks receiver left the game with an injury and missed a lot of the second half, but did play in the fourth quarter. Monitor his status throughout the week, but his return means he probably will suit up next week.
Doug Baldwin's workload has the most to gain if Lockett sits.
After two very productive weeks, the Garoppolo era in New England could be over quicker than expected. He will in all likelihood not start on short rest in Thursday night's game against the Texans and Tom Brady returns in Week 5.
The poor Browns can't catch a break. After a solid performance in a Week 2 loss to the Ravens, McCown will be replaced by Cody Kessler. It will be the third starting QB in 3 weeks for Cleveland.